Objective: To investigate the correlation among single nucleotide polymorphisms (SNPs) of CRP gene -286 and susceptibility of KD in the late convalescence period of KD. Method: Genotyping were performed for the detection of SNP at positions -286 in 101 KD patients and 173 healthy children. The serum hs-CRP levels were measured by enzyme-linked immunosorbent assay (ELISA). The correlations of SNPs of CRP gene and susceptibility of KD, serum hs-CRP levels in the late convalescence period of KD were analyzed. Results: (1) frequencies of genotypes of A and/or T at position -286 of CRP gene were 45.1% in CAL group and 28.9% in control group (Χ2=5.491, P=0.019, OR=2.003, 95%CI, 1.116~3.594). The allele frequencies of the less common A+T variant were 26.5% in CAL group and 14.7% in control group (Χ2=4.185, P=0.041, OR=2.068, 95%CI, 1.023~4.180). (2)The serum of hs-CRP levels in CAL group, non-CAL group and control group were 3.42±1.66mg/l, 2.63±1.27mg/l and 2.61±1.27mg/l, respectively (P <0.05, P <0.01). (3)The serum of hs-CRP levels with CC, CA, CT, AT/AA/TT genotype at position -286 of CRP gene were 2.31±1.03mg/l, 3.55±1.59 mg/l, 3.28±1.56 mg/l and 3.85±1.69 mg/l, respectively (P <0.01). Conclusions: SNP at position -286 of CRP gene is associated with the susceptibility of KD. A and/or T alleles at position -286 of CRP gene might be regarded as genetic markers of risk factors for vascular lesions in late convalescence period of KD.