Relationship between Administration of Intravenous Immune-Globulin and Cardiac/Coronary Artery Leision in patients with Kawasaki Disease

  • Dr Guo-Ying Huang, Children's Hospital of Fudan University, Shanghai, China
  • Dr Li-Jian Xie, Children's Hospital of Jiaotong University, Shanghai, China
  • Dr Chen-Yan Yu, Children's Hospital of Fudan University, Shanghai, China
  • Dr Min Huang, Children's Hospital of Jiaotong University, Shanghai, China
  • Dr Shu-bao Chen, Shanghai Children's Medical Center, Shanghai, China
  • Dr Mei-rong Huang, Shanghai Children's Medical Center, Shanghai, China
  • Dr Rong-fa Wang, Xinhua Hospital of Jiaotong University, Shanghai, China
  • Dr Xiao-Jing Ma, Children's Hospital of Fudan University, Shanghai, China

    • [Abstract]
    Objective To evaluate the effectiveness of intravenous immuno-globulin (IVIG) in treating and preventing cardiac consequences(coronary artery lesion, CAL)of patients with Kawasaki disease (KD). Method A questionnaire form and guideline for KD were sent to 50 hospitals in Shanghai, which provided with pediatric medical care. 1682 KD patients were recoeded from January 1998 through December 2007, which included 1064 males and 618 females. The median age of KD patients was 2.57±2.33 years old (0.1~18.8 years). Six therapy schemes of IVIG were administered including 1g/kg×once, 2g/kg×once, 0.4~0.5g/kg× five times, 1g/kg×twice, 2g/kg×twice and other. Results Among all, the lower incidence of CAL complications (16.8%) was shown in patients with IVIG administration during 5~10 day of illness. Lower incidence of CAL complications (16.9%) was shown in patients with IVIG administration of 1g/kg×twice. Conclusion The best therapy of IVIG in KD patients is 1g/kg×twice and it should be used in 5~10 day of KD illness.

    [Keyword] Kawasaki Disease, intravenous immunoglobulin, coronary artery lesion