Tetralogy of Fallot: any correlation between echocardiographic measures, radionuclide angiography and (gold standard) MRI?

  • Dr D Zentner, Royal Melbourne Hospital, Australia
  • Dr A Ellims, Royal Melbourne Hospital, Australia
  • Dr D Sivaratnam, Royal Melbourne Hospital, Australia
  • Dr Michael Cheung, The Royal Children's Hopsital, Melbourne, Australia
  • Dr L Grigg, Royal Melbourne Hospital, Australia
  • Objective
    To determine whether correlations exist between echocardiography (TTE), radionuclide angiography (RNA) and magnetic resonance imaging (MRI) assessment of the right ventricle (RV) in adults post TOF repair.
    Methods
    Prospective MRI assessment and data comparison with most recent TTE and RNA. Data is presented as median (interquartile range).
    Results
    MRI has been performed 28.8(23.6 – 33.8) years post repair (y) in 33 patients, of whom all have had TTE (29.6 (25.2 – 35.0) y) and 26 have had RNA (26.4 (22.3 – 31.8) y). The cohort are 30.3 (27.0 – 39.0) years old; with a gender ratio18:15 (F:M) and MRI RVEDVI of 152 mLs/m2 (120 – 187). Data collection and analyses are ongoing, with interim analysis demonstrating moderate correlation between TTE RV size and MRI RV volume and pulmonary regurgitation (PR) (mLs) (Table 1).
    Conclusion
    TTE measures of RV size correlate with MRI RVEDI and PR volume. No correlation was found between pulse wave TDI and MRI RVEF, despite the premise that increasing RV size would be associated with decreasing function. Objective assessment of RV function remains a challenge.

    Correlation variables TTE RVOT size TTE RV base size
    MRI RVEDVI r = 0.6 2p = 0.002 r = 0.4 2p = 0.019
    MRI PR r = 0.6 2p = 0.01 r = 0.6 2p = 0.003