Objective:Aim to investigate and compare the ventricular function of perimembranous ventricular septal defect(VSD) patients after transcatheter closure and surgical repair by Doppler tissue imaging (DTI).Methods:Seventy-seven age-matched consecutive patients underwent perimembranous VSD closure: 35 patients were treated with transcatheter occluder at age of 5.4±3 years and 42 patients were treated surgically at age of 4.8±2.6 years. Ventricular function was assessed using DTI and conventional echocardiography at 0.8±1 year (from 1month to 30months) after VSD closure.Results:There was a significantly higher mitral annular myocardial systolic velocity in patients with occluder closure (9.03±2.07cm/s vs 7.16±1.02cm/s, p<0.001) than those after surgical repair, although the end-diastolic volume and ejection fraction of left ventricle(LV) measured by conventional echocardiography and the LV myocardial performance index (MPI), mitral annular isovolumic contraction acceleration (IVA), early (e) to late (a) diastolic mitral annular velocity ratio calculated by DTI were all similar (p=NS). More interestingly, all right ventricular(RV) parameters excepting tricuspid annular e/a ration (p=NS) measured by DTI were significantly better in occluder patients: the RVMPI was lower (0.32±0.07 vs 0.39±0.08, p=0.019); the tricuspid annular IVA (2.46±0.94m/s2 vs 1.60±0.33 m/s2, p=0.003) and myocardial systolic velocity (12.69±2.56 cm/s vs 8.98±1.59 cm/s, p<0.001) were both higher. In both cohorts of the patients, the size of the VSD was no significant difference (5.92±1.7mm vs 6.92±2.58mm, p=NS).Conclusion:In our small sample study, the transcatheter closure of perimembranous VSD is promising technique that can be used in suitable cases, which is probably helpful to reserve the ventricular function, especially the RV function. Further and large-sample studies are required.