Epidemiologic Research of Kawasaki Disease in Shanghai From 2003 Through 2007

  • Dr Guo-ying Huang, Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China
  • Dr Chen-yan Yu, Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China
  • Dr Min Huang, Children's Hospital of Jiaotong University, Shanghai, China
  • Dr Shu-bao Chen, Shanghai Children's Medical Center, Shanghai, China
  • Dr Mei-rong Huang, Shanghai Children's Medical Center, Shanghai, China
  • Dr Rong-fa Wang, Xinhua Hospital of Jiaotong University, Shanghai, China
  • Dr Xiao-jing Ma, Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China
  • Dr Fang Liu, Pediatric Heart Center, Children's Hospital of Fudan University, Shanghai, China

    • Objective To investigate the epidemiologic feature of Kawasaki disease (KD) in Shanghai from 2003 through 2007. Methods All patients in this survey were identified by the discharge diagnosis code in medical records with KD in 50 hospitals providing pediatric care in Shanghai during January 2003 through December 2007. Results A total of 1187 qualified patients with KD were reported. The incidence rate for each year: 43.06 (2003), 53.28 (2004), 50.35 (2005), 48.12 (2006), and 36.78 (2007) per 100,000 children under 5 years of age. The age of onset ranged from 12 days to 13.6 years (median 1.75 years) , and 30% of patients are under 1 year of age. The male/female ratio was 1.70:1. Fever (98.5%) was the most common clinical symptom, followed by oral changes (86.4%), extremities desquamate (82.7%), conjunctive congestion (81.5%), rash (75.8%), lymphadenopathy (63.4%), and crissum desquamate (42.5%). Cardiac abnormalities were found in 24.2% of patients by echocardiography. The most common cardiac abnormality was coronary artery lesions including ectasia (64.1%) and aneurysm (17.6%). The fatality rate at acute stage of the disease was 0% in this study. A second onset of the disease occurred in 1.2% of patients. Conclusions Although the incidence of Kawasaki disease in Shanhai tends to increase, it is still lower than that reported in Japan. Sex and age distributions, clinical symtoms and rates of recurrence and cardiac lesion are similar to those in previous reports.

    Keywords: Kawasaki disease; Shanghai; Epidemicology;Cardiac sequelae