Comparative Changes of Pulmonary Artery Pressure Values and Tricuspid Valve Regurgitation Following Transcatheter Closure of Atrial Septal Defects in Adult and Elderly Patients

  • Dr Avraham Lorber, Pediatric Cardiology and GUCH, Meyer Children's Hospital, Rambam Healthcare Campus,, Israel
  • Dr Sergey Yalonetsky, Pediatric Cardiology and GUCH, Meyer Children's Hospital, Rambam Healthcare Campus,, Israel
  • Dr Yitzhak Schwartz, Pediatric Cardiology and GUCH, Meyer Children's Hospital, Rambam Healthcare Campus,, Israel
  • Dr Assad Khoury, Pediatric Cardiology and GUCH, Meyer Children's Hospital, Rambam Healthcare Campus,, Israel
  • Dr Yulia Braver, Pediatric Cardiology and GUCH, Meyer Children's Hospital, Rambam Healthcare Campus,, Israel
  • Dr Liat Gelernter-Yaniv, Pediatric Cardiology and GUCH, Meyer Children's Hospital, Rambam Healthcare Campus,

    • Objective: Opinions vary widely regarding the transcatheter closure of the atrial septal defect (ASD)in adults and especially in elderly patients.The purpose of this study was to evaluate and compare the hemodynamic changes after Transcatheter closure of ASD in two groups of patients, one aged 40-59 years (group 1) and one 60 years of age and older (group 2).
    Methods: retrospective analysis of patients' files.
    Results: 46 patients were evaluated (23 in each group). Older patients had a higher prevalence of cardiovascular risk factos and establishes coronary aretry disease. There was no statistically significant difference between the two groups in Qp/Qs values, ASD diameter and occluder size. The elderly patients had significantly higher baseline systolic pulmonary artery pressure (PAp)levels -53±16.2 vs. 39±7.7 mmHg (p=0.003). One year following the procedure the mean reduction in PAp values was 11.3% in group 1 and 19% in group 2(p=0.009). While significant tricuspid regurgitation (TR) was more frequent in the elderly patients, no significant TR was observed in either group one year following the procedure. Conclusions:Transcatheter ASD closure resulted in significant hemodynamic improvement in all patients, but was even more beneficial in the elderly patients.