Background: Neurocognitive complication after cardiac surgery with Cardiopulmonary bypass (CPB)is a common complication (in up to 53% of patients). In many patients this complication is only mild and transient, but in 5% of cases, it is severe.

Method: In this prospective study, from June 2002 to July 2004, in Rajaee Heart Center 186 patients were operated as on- pump or off-pump Coronary artery bypass graft(CABG) ,they were evaluated for neurocognitive complications by mini-mental status test examination.

Results: Average age of the patients was 56±6.2 years, 62% were male and 38% were female. 121 patient were operated as on-pump and 65 patient were operated off-pump. Mini-mental status test examinations were normal in 50% of off-pump operations and in 43% of on-pump operations, very mild disturbance were seen in 48% of off-pump operations and in 54% of on-pump operations (p-value=0.192,NS), mild disturbance were seen in 2% of off-pump and in 3% of on-pump surgeries(p-value 0.392, NS). Moderate or severe disturbances were not seen in any groups.

Conclusion: In our studies there was not significance difference in neurocognitive complication between off-pump and op-pump pump Coronary artery bypass graft(CABG) .

Key Words: Neurocognitive complication; Cardiopulmonary bypass,Coronary artery bypass graft