Markers of myocardial damage after percutaneous radiofrequency catheter ablation in children with tachyarrhythmias

  • A/Prof Katarzyna Bieganowska, Department of Cardiology, The Children’s Memorial Health Institute, Warsaw, Poland
  • Dr Maria Miszczak-Knecht, Department of Cardiology, The Children’s Memorial Health Institute, Warsaw, Poland
  • Dr Lukasz Szumowski, Cardiac Arrhythmias Department, Institute of Cardiology, Warsaw, Poland
  • Dr Monika Brzezinska-Paszke, Department of Cardiology, The Children’s Memorial Health Institute, Warsaw, Poland
  • Dr Joanna Rekawek, Department of Cardiology, The Children’s Memorial Health Institute, Warsaw, Poland
  • A/Prof Roman Kepski, Cardiac Arrhythmias Department, Institute of Cardiology, Warsaw, Poland
  • Agnieszka Kaszuba, Department of Cardiology, The Children’s Memorial Health Institute, Warsaw, Poland
  • Prof Franciszek Walczak, Cardiac Arrhythmias Department, Institute of Cardiology, Warsaw, Poland

    • Introduction: Radiofrequency (RF) catheter ablation produces endomyocardial necrosis by way of resistive heating of the tissue in contact with the catheter tip electrode. It may result in release biochemical markers of myocardial cell damage. The aim of the study was to check the levels of markers of myocardial tissue damage in children undergoing ablation RF. Methods and results: In 168 children with tachyarrhythmias (mean age 14,9 years) blood samples were taken before ablation (baseline), and next 6-8 hours and 3 days after the procedure. The lactate dehydrogenase (LDH), creatine kinase – MB (CK-MB), creatine kinase (CPK) and troponin levels were measured. Results: Mean baseline enzyme levels were: LDH – 170,1 U/l, CPK - 95,1U/l, CK-MB - 4,12 U/l, troponin – 0 ng/ml, early hours post ablation: LDH – 165 U/l, CPK - 112,6 U/l, CK-MB - 5,66 U/l, troponin – 1,244 ng/ml, 3 days after the procedure: LDH – 167,7 U/l, CPK - 79,5 U/l, CK-MB - 4,28 U/l, troponin – 0,168 ng/ml. In children CPK, CK-MB and troponin levels significantly increased early after catheter ablation, then after 3 days CK-MB normalised, troponin level decreased slowly, CPK level was lower compare to baseline level, LDH level was stabile after the procedure. Conclusion: In children undergoing catheter ablation level of CPK, CK-MB and troponine significantly increased after the procedure as a marker of myocardial damage.