Long term outcome of Chagas´s Disease in the childhood

  • Dr Cunha Borges da Cunha, Federal University of Uberlândia, Medicine´s Faculty (UFU-FAMED), Brazil
  • Dr Gomes Gonçalves Gomes, Federal University of Uberlândia, Medicine´s Faculty (UFU-FAMED), Brazil
  • Dr Silveira Lopes da Silveira, Federal University of Uberlândia, Medicine´s Faculty (UFU-FAMED), Brazil
  • Dr Baraúna Ramos Diniz Baraúna, Federal University of Uberlândia, Medicine`Faculty (UFU-FAMED), Brazil
  • Dr Cisdelli Cristiane Cisdelli, Federal University of Uberlândia, Medicine´s Faculty (UFU-FAMED)
  • Dr Faria Aparecida Faria, Federal University of Uberlândia, Brazil
  • Dr Mantese Cesar Mantese, Federal University of Uberlândia, Medicine´s Faculty (UFU-FAMED), Brazil
  • Dr Cunha Ribeiro da Cunha, Federal University of Uberlândia, Medicine´s Faculty (UFU-FAMED), Brazil
  • Objective: since Chagas´s Disease (CD) is most prevalent in Brazil children we performed to review of epidemiological, clinics and outcome’s data in 7 patients (pts) with special focus on the long term once cardiac form are rarely detected in childhood.

    Methods: prospective study on 7 pts with DC between March 1993 to November 2008 (15y) with exams previous and long term outcome´s data, and follow-up reports. Participating considered for the study having signed the informed consent term from the their parents.

    Results (data summarizeds in Table 1): median age 9.8 (range 5y to 15y) endemics cities´founded, 43% urban, without inoculation´s chagoma, on forms: 2 acute, 4 chronic, 1 undetermined. Benzonidazole drugs were used in acute form (2). Three pts aren’t symptoms (2 acute, 1 undetermined). One child (8y) died due to severe dilated myocardiophaty (DM) in the others remain symptomatic.

    Conclusions: the contagious form not performed prognosis factor. The full picture of the outcome in heart chronic form remains hazy including myocardial and conduction system lesion. In the meantime continuing collaborative efforts among various prevalent centers will help define the optimal management, to contribute to the improvement of treatment strategies and even DC prevention.

    Age (y) Clinic form Transmissibility Clinc data Cardiac data
    10 Acute Kidney' s TX Fever Myocarditis
    12 Acute Inapparent CHF Myocarditis
    *8 Chronic Inapparent Fatigue DM
    8 Chronic Hemotransfusion Precordial pain DM
    15 Undetermined Inapparent Prenatal None
    9 Chronic Inapparent Chronic CHF DM
    10 Undetermined Inapparent Chronic CHF DM
    * dead