Purpose : Kawasaki disease can cause cardiovascular complications if not properly treated from the beginning. Recently, serum amyloid A (SAA) was reported to be a predictive factor of cardiovascular diseases. Therefore, it was examined whether the existence of coronary artery abnormality in Kawa-saki disease can be predicted in acute stage.
Methods : Firty nine patients who were diagnosed with Kawasaki disease between October, 2006 and May, 2007 at Yonsei University, Wonju College of Medicine were selected for this study. We reviewed results of CBC, AST, ALT, CK, LDH, total bilirubin, albumin, CRP, CK-MB, troponin-I, LDL, HDL, SAA, ESR, We divided the patients into two groups: Group A consisting of patients woth coronary artery lesions, and group B consisting of patients without coronary artery lesions. Results : CRP was significantly higher in group A (group A 11.0±7.0 mg/dL vs group B 5.3±5.3 mg/dL, p=0.030). SAA was slightly higher in group A but did not show any statistical significance (group A 283.8±357.3 ㎍/ml vs group B 133.2±293.4㎍/ml, p=0.128). Binary regression analysis was used to identify the significance of SAA as a predictor of coronary abnormality but did not find any significance (SAA OR=1.000, 95% CI=0.998-1.002, P=0.950).
Conclusion : SAA are not significant predictors of coronary artery abnomality in Kawasaki disease but are non specific factors which increase in the acute stage