Type-B natriuretic peptides are synthesized by the cardiac miyosits as a response to increased wall stress,and after being excreted as prohormone, they are separated as an active hormone (BNP) and Nt-proBNP which includes the inactive N-terminal part biologically.
In this study, our aim is to see the Nt-proBNP values of the patients who had congenital cardiac surgery and also if there is any relationship between their levels and the postoperative progress , mortality and morbidity.
For this purpose, the patients who had left-right shunt lesion and ventricular outflow tract obstruction were seperated in two groups as the ones who were in need of high dose (>7,5 mcg/kg/min) inotropic treatment and as the ones who were not in need or low dose inotropic treatment during the postoperative intensive care followup . The Nt-proBNP values of the patients were measured before the surgery and after the second (T1) and the twenty-fourth (T2) hours of the surgery. Additionally, postoperative inotropic treatment needs, and duration ; cardiopulmonary by- pass (CPBS) , cross-clamp (KK) , and mechanical ventilation (MVZ) time of the patients were recorded.There was statistically high meaningfull among the inotropic treatment period, mechanical ventilation period, and staying in intensive care period.
In our study, it was observed that there was a correlation between the inotropic treatment dose and duration time and the Nt-proBNP level; the average level of serum Nt-proBNP level was found as 1009,10±1345,43 pg/ in patients who were in need of high dose inotropic treatment.