Transposition of the great arteries(TGA)with posterior aorta was firstly reported in 1971 and the first successful arterial switch operation was not accomplished until 1990. We reported 6 infants of TGA with posterior aorta during 1993 and 2005 of which underwent arterial switch operation. The other died before operation. The age at operation ranged 8 days to 7 months old. All of them received cardiac catheterization and balloon arterial septostomy before operation. Typical picture of ventricular arterial discordance with aorta located posterior to the main pulmonary artery was delineated. We performed arterial switch operation without Lecompte maneuver in all the five patients. The ventricular septal defects (VSD) were closed through the native aortic root after aortic transaction. All but one of the five patients were doing well during follow-up except mild to moderate pulmonary stenosis. We concluded TGA with posterior aorta could be successfully corrected by arterial switch operation during early infancy. VSD closure through native aortic root and no Lecompte maneuver were recommended. There is no late mortality.