Japanese multi-center clinical study of total anomalous pulmonary venous connection

  • Kisaburo Sakamoto, Shizuoka Children's Hospital, shizuoka, Japan
  • Yuko Tosaka, Shizuoka Children's Hospital, shizuoka, Japan
  • Hidefumi Kishimoto, Japan
  • Toshihide Asou, Kanagawa Children's Medical Center, Japan
  • Arata Murakami, The University of Tokyo, Japan
  • Hiroshi Imoto, Kyushu Kouseinenkin Hospital, Japan

    • Objectives: It is said that operation results of total anomalous pulmonary venous connection (TAPVC) have been improved with the times, and some leading institutes had reported the excellent results of it. However there were not so many multi-center reports from any countries. In this report, we would like to talk about the exact results and consideration of TAPVC therapy in Japan, through multi-center data.
    Methods: One hundred thirty-one patients with surgical repair of TAPVC from 1998 to 2007, who had no additional cardiac anomalies, were collected from 5 institutes among Japanese Congenital Heart Surgeon’s Society group. We divided the whole into four groups (G-supra: 62 pts, G-cardiac: 21 pts, G-infra: 37 pts, G-mixed: 11 pts) and made some analysis retrospectively.
    Results: Median day and body weight at TAPVC repair: G-supra 17days/3.4kg, G-cardiac 26days/3.5kg, G-infra 8days/3.0kg, G-mixed 53days/3.3kg.
    Postoperative survival rate(%) at 1 year and 10 years: all groups 92.4/90.5, G-supra 91.9/91.9, G-cardiac 95.2/90.5, G-infra 94.6/90.5, G-mixed 81.8/81.8.
    Freedom from postoperative pulmonary venous obstruction(%) at 3 months, 1 year and 10 years: all group 82.3/77.2/69.0, G-supra 84.1/80.4/78.3, G-cardiac 85.2/73.9/73.9, G-infra 81.1/78.4/53.4, G-mixed 70.0/60.0/60.0.
    Conclusions: Postoperative results of TAPVC have acceptably improved in this decade and death after 1 year from TAPVC repair was rare, even in the groups of infracardiac and mixed type. However postoperative pulmonary venous obstruction have been also a major cause of early death yet.