Patients with congenitally corrected transposition of great arteries (CTGA) or with TGA treated by Sennings repair have a morphologic right ventricle RV in systemic position.
The aim of the present study was to assess the exercise capacity in adult patient with TGA with systemic right ventricle based on cardiopulmonary exercise test (CPX).
Material and methods: We investigated 35 patients ( 12 CTGA, 23 TGA after Sennings repair;) aged 18 to 56 mean 27,6±12,2 years in NYHA I -III - group 1 and 20 healthy controls aged 18 to52 mean 26,1±11,0 years - group 2. All the subject underwent echocardiography and symptom limited cardiopulmonary exercise test CPX. Ejection fraction (EF) of the systemic ventricle was measured using Simpsons method. We analyzed parameters of CPX: exercise time -T (min), oxygen uptake at anaerobic treasure - VO2AT (%VO2max), peak oxygen uptake - VO2peak (ml/kg/min), peak ventilatory equivalent for carbon dioxide -VE/VCO2peak.
Result: In patients group the mean systemic EF was 42,4±4,6 %. We find positive correlation between VO2peak and patients age. Result show table 1.
Conclusion:
Compared with control adult patients with congenitally corrected transposition of great artery show a shorter duration of exercise, lower oxygen uptake and increased ventilatory response at given workload. The exercise tolerance is decrease with age.