Objective: The goal of the study was to assess the health related quality of life (HRQoL) in children with mitral valve prolapse (MVP). Methods: The prospective study involved 67 patients of Department of Pediatric Cardiology with MVP, 47 girls and 20 boys, aged 8-18 years (average 13,9 ±2,61 years). Control group consisted of 31 healthy children, matched according to age and sex. We used Polish version of Kidscreen-27 to access health related quality of life. Kidsceen-27 is an international self-reported questionnaire for children and consists of 27 items which are used to assess HRQoL across 5 dimensions: physical well-being (maximal number of points to achieve 25), psychological well-being (max 35 points), autonomy and parent relation (max 35 points), peers and social support (max 20 points), school environment (max 20 points). Results: The results are presented in the table. The statistically significant difference was found only for one dimension of HRQoL – physical well-being (explores the level of child’s physical activity, energy and fitness). Conclusion: Children with mitral valve prolapse demonstrate similar quality of life compared to healthy children, except of physical well being which is significantly lower.