OBJECTIVES: To introduce 25 years Solid Collaboration between Project HOPE and Shanghai Children’s Medical Center(SCMC) and its contribute to the progress of pediatric cardiac surgery in SCMC.METHODS(HISTORY): Since 1985, Project HOPE has sent her cardiac team to Xinhua Hospital, Shanghai every year. Young doctors were sent to USA leading institutions for extended periods of training and clinical observation. Projest Hope also supported Shanghai government to build a new hospital-SCMC, which includes one heart center with nearly 250 beds. RESULTS: SCMC has became one of the biggest clinical medical centers for pediatric CHD in China. The Heart Center of SCMC has performed almost all procedures for complex CHD, including hypoplastic left heart syndrome (HLHS), TGA, pulmonary atresia with intact ventricular septum (PA/IVS), pulmonary atresia with VSD (PA/VSD), DORV, total anomalous pulmonary venous connection (TAPVC), etc. In 2007, the cardiovascular surgery team performed 2,850 procedures of CHD cases. This substantial number of cases probably is one of the largest quantities in CHD repair of the world. CONCLUSIONS: This successful collaboration is a great example of medical exchange and support between developing and developed countries. It created a cascade reaction in the field of CHD surgery in China.